Archive for August, 2011

There is a fundamental bias in assessing adaptive response to chronic radiation exposure.

August 26, 2011

Editors, I cannot agree with the too generic statement of paper conclusion (1). As a matter of facts, not all “cardiologists”, are created equal! I mean that the Authors ignore both Quantum Biophysical-Semeiotic Constitutions, and their related Inherited Real Risks, I have discovered and described in larger Literature (2-17). For instance, regarding type 2 DM and Cancer, solid and liquid, a 55 year -long, well-established, clinical experience allows me to state that either ignoring or overlooking the real existence of Quantum Biophysical Semeiotic Constitutions, including diabetic Constitution and Oncological Terrain (http://www.semeioticabiofisica.it), as well as related Inherited Real Risks, bedside evaluated in a quantitative way, we cannot prevent and diagnose type 2 DM and cancer promptly, even in initial stage, bringing about an overlooked today’s epidemics: Psychological Jatrogenetic Terrorism (2-5). In fact, authors around the world are thinking wrongly that ALL individuals are born equal so that all may be involved, e.g., by diabetes and malignancy. As a consequence, all individuals have undergo to laboratory investigations, as tumour biomarkers assessment, therefore spending uselessly NHS money, causing Psychological Jatrogenetic Terrorism, physician’s energy and time loss. As a matter of fact, e.g., women can be involved by Oncological Terrain, even with or without precise location of inherited cancer real risk in a well defined breast quadrant (“ab posse ad esse non licet illatio”, Kant, Kritik der reinigen Vernunft) (6). I think that because congenital functional mitochondrial cytopathology is overlooked – a “conditio sine qua non” of the most frequent and dangerous human disorders, including malignancies – current clinical researches are fundamentally biased. In other words, one does not consider the existence or assess the seriousness as well as the location of a mitochondrial cytopathy, I termed Congenital Acidosic Enzyme-Metabolic Histangiopathy, inherited by mother, conditio sine qua non of both Oncological Terrain and, consequently cancer “real risk” (3-5). In fact, both environmental risk factors and every drug, including oestrogens, suggested as a risk factor for breast cancer, “could” influence some human biological functions and/or bring about different disorders, such as cancers, exclusively in relation to both the presence and intensity of CAEMH in a well-defined biological system. For instance, despite either the well-known negative influence of radiation, and oral contraceptive use or the beneficial, positive effects of selective cyclooxygenase-2 (COX-2) inhibitors on breast oncogenesis (2) we have to consider the importance of the “genetic predispositions”, i.e., Oncological Terrain, as far as the onset of a lot of disorders is concerned, including breast cancer. To summarize, we need at first, i.e., starting whatever screening or research, to investigate the presence and intensity of CAEMH in the tested population, i.e., in every, single patient, and soon thereafter assessing presence, intensity of the CAEMH-dependent, Oncological Terrain, and the precise location of cancer congenital real risk, both always develop on the basis of the above -mentioned congenital mitochondrial cytopathy. Really, without this alteration of psycho- neuro-endocrine-immunological system, oncogenesis is not possible, as allows me to state my long clinical experience with Quantum Biophysical Semeiotics, Single Patient Based Medicine theory is based on (7). Finally, these pathological conditions are characterized by microcirculatory remodelling, wherein a central role is played by newborn- pathological, type I, subtype a), i.e., oncological , Endoarteriolar Blocking Devices (2-6,15-17). The above mentioned advances in physical semeiotics will play a central role in the future pre-primary (Manuel’s Story, Journal of Quantum Biophysical Semeiotics,http://www.sisbq.org/qbs-magazine.html) and primary prevention of common and dangerous disorders.

References

1)Gian Luigi Russo,Idolo Tedesco, Maria Russo, Angelo Cioppa, Maria Grazia Andreassi, and Eugenio Picano. Eur. Heart J. 2011 0:ehr263v1- ehr263; doi:10.1093/eurheartj/ehr263.  Cellular adaptive response to chronic radiation exposure in interventional cardiologists.

2)Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it

3) Stagnaro Sergio. There is another clinical, and overlooked tool, reliable in breast cancer prognosis evaluation http://www.biomedcentral.com/1471-2407/5/70/comments#204473 2005

4) Sergio Stagnaro Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer (21 December 2005). Cancer Cell International http://www.cancerci.com/content/5/1/34/comments#218502

5) Stagnaro S. Stagnaro S., Stagnaro-Neri M., La Melatonina nella Terapia del Terreno Oncologico e del “Reale Rischio” Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica_2.htm

6) Stagnaro-Neri M., Stagnaro S. Cancro della mammella: prevenzione primaria e diagnosi precoce con la percussione ascoltata. Gazz. Med. It. – Arch. Sc. Med. 152, 447, 1993

7) Stagnaro S., Stagnaro-Neri M., Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm

8) Stagnaro Sergio. Clinical tool reliable in bedside early recognizing pancreas tumour, both benign and malignant. World Journal of Surgical Oncology 2005, 3:62 doi:10.1186/1477-7819-3-62, 2005

9) Stagnaro Sergio. Bed-Side Evaluating Breast Cancer Real Risk. World Journal of Surgical Oncology. 2005, 3:67 doi:10.1186/1477-7819-3-67. 2005 2005

10) Stagnaro Sergio. Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer (21 December 2005). Cancer Cell International http://www.cancerci.com/content/5/1/34/comments#218502 2005

11) Stagnaro Sergio. Cancer Risk Factors and Oncological Terrain. 2006. http://www.wjso.com/content/4/1/74/comments#247528 2006

12) Stagnaro Sergio. Without Oncological Terrain oncogenesis is not possible. CMAJ. 23 March 2007 http://www.cmaj.ca/cgi/eletters/176/5/646

13) Stagnaro Sergio. GPs , Biophysical Semeiotics, and bedside cancer diagnosis. 08 July 2007, International Seminar of Surgical Oncology, http://www.issoonline.com/content/4/1/11/comments#281539 , 2007

14) Stagnaro Sergio. Oncological Terrain and Inherited Oncological Real Risk: New Way in Malignancy Primary Prevention and early Diagnosis. International Seminars in Surgical Oncology, 2007. http://www.issoonline.com/content/4/1/25/comments#290565

15) Stagnaro Sergio. Bedside Biophysical-Semeiotic Diagnosis of Breast Cancer, since initial Stage. International Seminars in Surgical Oncology 2007, http://www.issoonline.com/content/4/1/21/comments

16) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, http://www.travelfactory.it, Roma, 2009.

17) Caramel S., Stagnaro S. The role of mitochondria and mit-DNA in Oncogenesis. Quantum Biosystems 2010, 2, 221-248, http://www.quantumbiosystems.org/admin/files/QBS%202(1)%20250-281.pdf

PS. This Manuscript was submitted to European Heart Journal as Comment to the paper, referred in Reference Number 1

but it was not posted.

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