Archive for July, 2011

Liver PPARs Quantum-Biophysical-Semeiotic Evaluation of Pre-Metabolic and Metabolic Syndrome, at Rest and under Stress Tests.

July 11, 2011

The metabolic syndrome, admittedly a multi-component riskfactor for CVD, may be more or lessstrongly linked with insulin resistance. In my opinion, neither the ATP IIInor the WHO definitions consider the many other similarly relatedCVD risk factors, such as age, physical activity, or historyof CVD events, not to speak of until now overlooked CVD Quantum-Biophysical-Semeiotic Inherited Real Risk, I’ve discovered, which proved to be, in my long clinical experience, conditio sine qua non of such macro- and micro-vessels disorders  (1-5).

Really, the Framingham risk equation, largely accepted by authors who ignore Quantum-Biophysical Semeiotics, does not unfortunately includeimportant CVD risk factors (e.g., previous CVD events, familyhistory), and has been shown to be much less useful than otherrisk equations in predicting future CVD events in people withdiabetes.

Other newly identified CVD risk factorshave been shown to be strongly associated with insulin resistanceand CVD, but, taking no knowledge on above-mentioned CVD congenital real risk, it is unclear if they should be added to the syndromeand given equal or greater weight than the current components [1-5].

Because the criteria for the syndrome will capture individualswith frank disease (e.g., diabetes, hypertension, dyslipidaemia, microalbuminuria,clinical CVD), as well as people with far milder forms of the sameconditions, it is likely that there is a risk gradient for CVDevents among patients with both Pre-Metabolic and Metabolic Syndrome.

First of all, without CVD quantum-biophysical-semeiotic inherited real risk, CVD is not possible, despite presence and seriousness of all components of Metabolic Syndrome. Thus, the definitionwill capture a spectrum of severities, and it is likelythat a person who satisfies the diagnostic criteria with riskfactor levels just over the cut point will have a much lowerCVD risk than another individual with the same combination buthigher risk factor levels (4).

Such as problem solution is far more practical and exhaustive with the aid of Quantum-biophysical Semeiotics, as well as less expensive than that ofthe Framingham and UKPDS (U.K. Prospective Diabetes Study) risk models, in which the spectrum of severities is weighted,  so that it is clear who may be at greater or lesser risk. In addition, all authors, who have been studying Metabolic Syndrome, do not know Pre-Metabolic Syndrome, that comes first for decades in individuals involved by some quantum-biophysical-semeiotic constitutions and related congenital real risks, as I illustrated in earlier articles [1-5].

Interestingly, all around the world, physicians can now-a-days utilize easily an original clinical tool, among a lot of others, reliable and efficient in recognising and monitoring  individuals with diabetic and/or dyslipidemic and/or arteriosclerotic and/or hypertensive and/or gouthy, a.s.o., quantum-biophysical-semeiotic constitutions, slowly evolving firstly to Pre-Metabolic and then to Metabolic Syndrome (2).

As a matter of fact, physicians can bedside evaluate PPARs activity in the liver, adipose tissue, and skeletal muscles  by means of Quantum-biophysical Semeiotics (www.semeioticabiofisica.it,  Practical Applications), as suggested briefly in following.

Whereas it’s sufficiently  known the role of PPARs (especially γ) in regulating adipocyte differentiation and insulin-responsive glucose up-take, at my best knowledge, no author knows the possibility to utilize liver PPARS (α) activity bedside evaluation of glucose-lipid metabolism, in assessing Pre-Metabolic Syndrome, and monitoring its slow evolution to Metabolic Syndrome.

Interestingly, such assessment can be performed at the bedside in individuals at rest, and soon thereafter, under stress tests, i.e., stimulating PPARs with endogenous Melatonin, Thyroid hormones, and adipokine, obtained respectively, e.g., by closing both eyes, stimulating thyroid trigger-points, i.e., pinching the skin upon thyroid gland (= trigger points of thyroid), and finally by pinching adipose tissue of lateral abdominal regions  (= adipokine secretion). For further information about aspecific gastric reflex evaluation, See www.semeioticabiofisica.it, Practical Applications, Technical Page N° 1, URL:

http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/pagina1stomaco_eng.doc

From diagnostic view-point, important is the rate of increasing PPARs activity in the second evaluation, i.e., under stress conditions, paralleling the efficiency of these nuclear receptors. As regards liver PPARs (α) bedside assessment, we can gather this way a large number of precious information on present glucose-lipid metabolism, surely more precise than all other laboratory data [1-10].

 

A) In health, lying down in supine position, relaxed and with open eyes to inhibit  melatonin secretion, “mean-intense” hand pressure applied on liver skin projection area brings about hepatic-aspecific gastric reflex, after a latency time of 8 sec. exactly. Moreover, reflex duration lasts less than 4 sec. (= paramount parameter value, paralleling the efficiency of hepatic Microcirculatory Functional Reserve, and thus informing on microcirculatory structure and function) (1-5). Such as result excludes local microcirculatory remodelling, and thus the presence of newborn-pathological Endoarteriolar Blocking Devices.

Under above-referred stress tests, or immediately after their stopping, latency time raises to the highest value, i.e., from basal value 8 sec. to 16 sec., doubling former value.

 

B) On the contrary, in individuals involved by both diabetic and dyslipidaemic constitutions, showing related Inherited Real Risk, basal hepatic-aspecific gastric reflex latency time, caused my “mean-intense” stimulation of liver trigger-points, results still 8 sec. (NN = 8 sec.), but reflex duration is 4 sec., indicating initial, pathologically modified, microcirculatory bed, i.e.,  microcirculatory remodelling, characterized by newborn-pathological,  type I, subtype b), aspecific, Endoarteriolar Blocking Devices, as demonstrates a more difficult, refined evaluation, based on the uretheral reflexes (1-5). Such data are really important from diagnostic viewpoint.  After stress tests, latency time raises to about 15 sec. (NN = 16 sec.),  augmenting of about 90% of basal value.

 

C) In individuals with Pre-Metabolic Syndrome, basal hepatic- aspecific gastric reflex latency time persists still 8 sec. (NN = 8 sec.), whereas reflex duration rises to 5 sec. (in health, less than 4 sec.), showing that metabolic disorder is evolving slowly. As above referred, reflex duration give precise, as well as rapid information about PPARs efficiency, allowing also the therapeutic monitoring.

Interestingly, soon thereafter stress tests, latency time raises to >13 <15 sec., i.e., about 70% of initial value, indicating  the worsening  of glucose-lipids metabolism impairment.

 

D) In patients with Metabolic Syndrome, the latency time of basal hepatic-aspecific gastric reflex decreases to about 7 sec. (NN = 8 sec.); reflex duration is clearly prolonged: > 5 sec. ≤ 6 sec.  In addition, either during dynamic tests or immediately after stress test stopping, latency time raises ≥ 12 < 13 (augmenting about 50% of basal value)

 

Finally, in overt diabetes and/or dyslipidaemia, basal hepatic-aspecific gastric reflex latency time may be pathologically lowered, less than 8 sec.  (NN = 8 sec.), especially in overt disorder,  but reflex duration is always prolonged as far as to its highest levels: ≥ 6 sec. Moreover, in health, under above-mentioned stress tests or soon thereafter, latency time rises in a significant manner to 16 sec. (double value than that at rest).

On thy contrary, in patients involved by glucose and lipid metabolism impairment, latency time either do not  change at all, or ameliorates, but no significantly, in relation to the severity of underlying disorder.

At this point, I remember the numerous quantum-biophysical-semeiotic signs and manoeuvres, which allow doctors to bedside evaluate, in reliable way, blood glucose level, insulin secretion, insulin receptor sensitivity  in every peripheral target tissue (10-19).

Finally, we must take into accounts the paramount diagnostic value of liver preconditioning: after exact 5 sec. since the end of first assessing hepatic PPARs, doctor performs a second evaluation.

In health, negative for both diabetic and dyslipidaemic constitutions, after preconditioning the reflex duration raises significantly from 8 sec. to 16 sec. , doubling basal value, as it happen under above-illustrated stress tests.

On the contrary, in case B) duration lowers from 16 sec. to 15 sec. or less, rather than increasing: the intensity of pathological reflex duration lowering parallels the seriousness of underlying metabolism impairment.

At this point,  I must emphasize that the absence of dyslipidaemic constitution among individuals is indeed very rear in my experience, occurring about 1 every 100 individuals, due perhaps to thrift genes.

In conclusion, aiming to realise an efficacious primary prevention of Pre-Metabolic and Metabolic Syndrome and its slow evolution towards various disorders on very large scale, in individuals rationally enrolled, doctors have to bedside recognize, possibly since birth, all subjects positive for dylsipidaemic and/or diabetic constitutions, conditio sine qua non of  dyslipidaemias and diabetes, when both conditions are associated.

Subsequently,  physicians have to ascertain the presence of related inherited real risks of dyslipidaemia and diabetes [1-5,20-25].

From the above remarks, the numerous suggested predictors of future cardiovascular events, as moderate elevations in CPR present in apparently healthy individuals [26-28], seem less significant than admitted now.

 

References

 

1. Stagnaro Sergio.  Pre-Metabolic Syndrome and Metabolic Syndrome: Biophysical-Semeiotic Viewpoint. www.athero.org, 29 April, 2009. http://www.athero.org/commentaries/comm904.asp

2. Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxigenation and Biophysical-Semeiotic Preconditioning. www.athero.org, 29 April, 2009  http://www.athero.org/commentaries/comm907.asp

3. Stagnaro S.  Metabolic Syndrome, even initial: diagnostic  Role of clinical, quantitative, biophysical-semeiotic PPAR Evaluation  by endogenous Thyroid Hormon and Melatonin.

http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Metabolic%20Syndrome%20PPARS%20engl.doc

4.  Stagnaro Sergio. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7;   [MEDLINE]

5.  Stagnaro S.     Bed-Side Biophysical-Semeiotic Evaluation of PPARs Activity.

http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/PPARs%20BS%20Evaluation%20eng.doc

6.   Stagnaro S.      Biophysical-Semeiotic bed-side Evaluation of Adiponectin in classic and variant Pre-Metabolic and Metabolic Syndrome. http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Adiponectin%20lavoro%20engl.doc

7. Stagnaro Sergio Biophysical-Semeiotic Bed-Side Evaluating PPARs Activity in Metabolic Syndrome.   Cardiovascular Diabetology. (19 September 2005)   http://www.cardiab.com/content/4/1/14/comments#211488

8. Stagnaro Sergio. Bedside biophysical-semeiotic PPARs evaluation in glucose-lipid metabosism monitoring. Annals of Family Medicine, 2007; 5: 14-20. http://www.annfammed.org/cgi/eletters/   

9. Stagnaro  Sergio.  Pivotal PPARs Activity Bed-side Evaluation in Pre-Metabolic Syndrome and Metabolic Syndrome Primary Prevention. Cardiovascular Diabetology. 2005, 4:13     doi:10.1186/1475-2840-4-13 2005

10. Stagnaro Sergio.  Pivotal Role of Liver PPARs Activity Bed-side Evaluation in Monitoring glucidic and lipidic Metabolism. Lipids in Healt and Disease. 02 June 2007, http://www.lipidworld.com/content/6/1/12/comments#284542 2007

11.   Stagnaro Sergio.  Biophysical-Semeiotic Diagnosis of Diabetes Mellitus since its initial stages.

http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Diagnosi%20Semeiotico-Biofisica%20del%20Diabete%20Mellito_eng.doc

12. Stagnaro Sergio.    Biophysical-Semeiotic Evaluation of Insular Amyloid in Bed-Side Diagnosing Diabetes Mellitus Type II, since Initial Stage.

http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Diagnosis%20DM,%20amyloid.doc

13.  Stagnaro Sergio. From Diabetic and Dyslipidemic Biophysical-Semeiotic Constitutions

to Type 2 Diabetes Mellitus. http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/A%20IIR%20Lipids%20Sem.%20Biof%20Engl.doc

14. Stagnaro Sergio. Beyond Hyperinsulinemia-Insulin Resistance in the War against Arteriosclerosis and type 2 Diabetes Mellitus. http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Beyond%20Hyperinsulinemia%20engl.doc

15. Stagnaro Sergio. Diabetic Constitution, Obesity, Insulin-Resistance, PPARs, and Type 2 Diabetes Mellitus.http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/A%20CD%20DM%20PPAR%20engl.doc

16.   Stagnaro Sergio. Beyond Glycemia: Biophysical-Semeiotic Evaluation of Glycemic Metabolism.   http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/AB%20Glicemia%20Valut%20SB%20engl.doc

17. Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: la manovra di Ferrero-Marigo nella diagnosi clinica della iperinsulinemia-insulino resistenza. Acta Med. Medit. 13, 125, 1997.

18. Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: valutazione clinica del picco precoce della secrezione insulinica di base e dopo stimolazione tiroidea, surrenalica, con glucagone endogeno e dopo attivazione del sistema renina-angiotesina circolante e tessutale – Acta Med. Medit. 13, 99 1997

19. Stagnaro-Neri M., Stagnaro S., Il Segno di Bilancini-Lucchi nella diagnosi clinica del diabete mellito. The Pract. Ed. It. 176, 30, 1993.

18. Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004. http://www.travelfactory.it/

21. Stagnaro S., Stagnaro-Neri M., Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Ed.Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm

22. Stagnaro  Sergio.  Biophysical Semeiotic Constitutions, Genomics, and Cardio-Vascular Diseases. BMC Cardiovascular Disorders http://www.biomedcentral.com/1471-2261/4/20/comments#95454 2004

23. Stagnaro Sergio. Teoria Patogenetica Unificata, 2006, Ed. Travel Factory, Roma.

24. Stagnaro Sergio.   Bedside diagnosing diabetic and dyslipidaemic constitutions and diabetes real risk. 2 October2006 http://www.cmaj.ca/cgi/eletters/175/7/733

25. Stagnaro Sergio.  Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

26. Ridker PM, Buring JE, Shih J. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation. 1998;98:731-733.

27. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836-43

28. Kervinen H, Palosuo T, Manninen V, Tenkanen L, Vaarala O, Mänttäri M. Joint effects of C-reactive protein and other risk factors on acute coronary events. Am Heart J. 2001;141:580-585.

Water Memory-Information containing Muscle Extremely High Energy Frequency: Is the Therapeutic Problem of Chronic Fatigue Syndrome solved?

July 7, 2011

Introduction.

As I wrote formerly (1), till July 1st, 2011, water memory was an argument of large discussion, really a conjecture.

In fact, nobody has ever proved that water is able of retaining a memory (I use also the term INFORMATION) of substances dissolved in it once to arbitrary dilution. In the referred paper,  precise information on utilizing Water Memory-Information was provided.

While some studies, including Benveniste’s, reported this effect, double-blind replications of the experiments involved have failed to reproduce the results, and the concept is not accepted by the scientific community.

On the contrary, I illustrated the CLINICAL, Quantum Biophysical Semeiotic Demonstration of Water Memory-Information, curing my gastroenterocolitis due to Gram-positive bacteria, I had been suffering from for 4 days (1).

Importantly, every my experimental evidence can be bedside reproduced easily and quickly, at the condition that scientists, who want reproduce it, know the quantum biophysical semeiotic method!

 

For 4 decades I have been suffering from Chronic Fatigue Syndrome (CFS), an unsolved therapeutic problem till now. Thanks to earlier treatment, based on free-radicals scavenger and anti-inflammatory drugs, I obtained partial and transitory benefit (2-8).

 

Chronic Fatigue Syndrome: State of the Art.

Chronic fatigue syndrome, CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Persons with CFS most often function at a substantially lower level of activity than they were capable of before the onset of the illness.

The fatigue of CFS is accompanied by characteristic symptoms lasting at least 6 months, including self-reported impairment in short-term memory or concentration, severe enough to cause substantial reduction in previous levels of occupational, educational, social, or personal activities; sore throat is frequent or recurring; tender cervical (neck) or axillary lymph nodes; muscle pain; multi-joint pain without swelling or redness; headaches of a new type, pattern, or severity; very common un-refreshing sleep and post-exertional malaise (extreme, prolonged exhaustion and sickness following physical or mental activity) lasting more than 24 hours.

However, many CFS patients may experience other symptoms, including irritable bowel, depression or psychological problems, chills and night sweats, visual disturbances, allergies or sensitivities to food, odours, chemicals, medications, or noise, brain fog, difficulty maintaining upright position, dizziness, balance problems or fainting.

 

CFS: the hypothesis 0, I cannot falsify.

Quantum Biophysical Semeiotics facilitates CFS diagnosis, as illustrated here after.

The hypothesis 0 to falsify was that in CFS skeletal muscles, a part from the possible causes of such a disorder, are altered from the structural and functional view-point: structure and function are two poles of the same equation!

As a consequence the relative energy frequency, gathered from skeletal muscles, e.g., biceps and quadriceps, was altered, too, so that after modifying it properly with Cem Tech, and retransmitting it to a glass of mineral water that patients swallow, physicians will ameliorate until normalize their muscle structure and function, especially regarding local mitochondria respiratory activity, altered in CFS.

As a matter of fact, such a water, thanks to Cem Tech, contains Information on the muscle physiological structure, conserving it as Memory for a time to prove – two days after the experiment beginning – results are present yet, as I am going to illustrate here after.

 

Quantum Biophysical Semeiotic Methods.

Basal QBS evaluation showed that, under “intense” (= such an adjactive is “quantitative”, rather than “qualitative”, indicating that it brings about upper ureteral reflex, typical of Artero-Venous Anastomoses (AVA) type A, group II, according to Bucciante) (19-13) digital pressure, latency time of (biceps and quadriceps) skeletal muscle-gastric aspecific reflex was 9 sec. (NN = 10 sec.); duration pathologically increased to 7 sec. (NN > 3 sec. < 4 sec.; paramount parameter value, paralleling the efficiency of local Microcirculatory Reserve Function); finally, the time of reflex disappearing lowered to 3 sec. (NN > 3 sec. < 4 sec., perfectly identical to fractal Dimension of local microvessel fluctuation, calculated in a really refined, but difficult, way) (9-12).

In addition, the Free-Radical QBS evaluation resulted positive, emphasising an high tissue level of oxygen reactive substances (8): at the second assessment, exactly 3 sec. after the basal evaluation, latency time of muscle-gastric aspecific reflex decreased  pathologically to 7,5 sec.

 

At this point, I have captured with Cem Tech two devices (crystals) frequency from my right biceps and respectively from my left quadriceps, for 1 minute.

Subsequently, after applying the two devices on myself on the same sites, cited above, I assessed for the second time the identical parameter values of skeletal muscle-gastric aspecific reflex.

Latency time of the reflex raised to 20 sec. (basal value = 9 sec.), as it happens in QBS physiological preconditioning (11, 12). Reflex duration decreased to 3 sec., showing a perfect muscle vessels Microcirculatory Functional Reserve. Finally, the time of reflex disappearing returned to normal value: > 3 sec. < 4 sec.

 

At this moment, I removed from my body Cem Tech crystals, emitting extremely high energy frequency, and immediately reflex parameters showed identical pathological parameter value, as those observed in basal examination, referred above.

 

At this point, I directed the extremely high frequency energy, contained by Cem Tech devices, towards the water, precisely mineral water, present in a glass, placed on the table 10 cm from my body, by applying the two crystals directly on the base of glass bottom for 10 min.

Starting from about 4 minutes, parameter values of the above illustrated reflex progressively ameliorated, and after less than 10 sec. they showed the values, typical of QBS physiological preconditioning.

Every observation was possible thank to, and enlightened by, n-DNA and mit-DNA Antenna theory, I demonstrated formerly (14, 15).

At this point, I went away from the water in the glass, as well as from Cem Tech devices: the evaluation of reflex parameter values resulted again in pathological ranges, showing the same data, referred above!

 

Soon after I drunk that energized water, I observed identical, significant increasing of all parameter values of muscle-gastric aspecific reflex: Latency time of the reflex raised to 20 sec. (basal value 9 sec.), characteristic of QBS preconditioning (11, 12). Reflex duration lowered to 3 sec., showing a perfect Microcirculatory Functional Reserve of muscle microcirculatory bed.

Finally, the time of reflex disappearing returned to normal value: > 3 sec. < 4 sec.;

Importantly, the cleaned glass was inactive, i.e., it did not bring about increasing of reflex parameter values!

Interestingly, two hours after the experiment beginning, all parameter values, illustrated above, were yet identical. I walked for 45 min. without feeling fatigue, like now while I am writing this Manuscript. Benveniste was right!

Interestingly, the above illustrated positive results lasted exactly for 14 hours; then all parameters values slowly decreased in the three subsequent hours until the latency time of skeletal muscle reflex decreased to 12 sec. (NN = 10 sec.); reflex duration lowered to 3 sec. (NN >3 sec.< 4 sec. indicating a perfect Microcirculatory Functional Reserve); finally, reflex disappearing time was 4 sec., showing that fractal Dimension of local microvessels oscillations was at highest value.

After  two days all parameters showed normal values.

Conclusion: the significant data of this quantum-biophysical-semeiotic experiment, illustrated in details from the technical view-point, aiming to treat Chronic Fatigue Syndrome, allows me to state that a “possible”, really efficacious therapy of CFS has been discovered, if it will be corroborated on a very large scale, of course.

 

References

1) Stagnaro Sergio.  First Water Memory-Information Demonstration through Quantum Biophysical Semeiotics. 1 July, 2011, https://stagnaro.wordpress.com/ ; http://www.sisbq.org/journal-of-quantum-biophysical-semeiotics1.html; http://www.sisbq.org/uploads/5/6/8/7/5687930/watermemoryinformation.pdf

2) Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemizzante diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17, 1990.

2) Stagnaro-Neri M., Stagnaro S., Acidi grassi ώ-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc. Med. 151, 341, 1992.

3) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Coenzyme Q deficiency Syndrome. VI Int. Symp., Biomedical and clinical aspects of Coenzyme Q. Rome, January 22.24, 1990,Chairmen K. Folkers, G.L. Littarru, T. Yamagani, Abs., pg. 105.

4) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239.

5) Stagnaro-Neri M, Stagnaro S. Co Q10 in the prevention and treatment of primary osteoporosis. Preliminary data. Clin Ter.;146(3):215-9 [MEDLINE]

6) Stagnaro-Neri M., Stagnaro S., La sindrome percusso-ascoltatoria da carenza di Carnitina. Clin. Ter. 145, 135, 1994 [Medline]

7) Stagnaro-Neri M., Stagnaro S., La sindrome percusso-ascoltatoria da carenza di Carnitina. Clin. Ter. 145, 135, 1992 [Medline]

8) Stagnaro-Neri M., Stagnaro S., Ketanserina: antagonista dei recettori 5Ht2-serotoninergici e scavenger dei radicali liberi. Clin. Ter. 141, 465, 1994 [Medline]

9) Stagnaro-Neri M., Stagnaro S., Deterministic chaotic biological system: the microcirculatoory bed. Theoretical and practical aspects. Gazz. Med. It. – Arch. Sc. Med. 153, 99

10) Stagnaro-Neri M., Moscatelli G., Biophysical Semeiotics: deterministic Chaos and biological Systems. Gazz. Med. It. – Arch. Sc. Med. 155, 125, 1996.

11) Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 13, 109, 1997.

12) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology. 2007. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

13) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Evaluation of Arterio-venous Anastomoses Dysfunction in early Arteriosclerosis. Acta Med. Medit. 5, 141, 1989.

14) Sergio Stagnaro. Ruolo del DNA Antenna nella Diagnosi Semeiotica Biofisica Quantistica dei Primi due Stadi del Diabete Mellito tipo 2. http://www.fcenews.it, 19 novembre 2010. http://www.fceonline.it/images/docs/dna_diabete.pdf; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/dna_t2dm.pdf

15) Simone Caramel and Sergio Stagnaro The role of glycocalyx in QBS diagnosis of Di Bella’s Oncological Terrain – http://www.sisbq.org/uploads/5/6/8/7/5687930/oncological_glycocalyx2011.pdf

Gentile’s Sign*: Bedside Diagnosing Acute Myocardial Infarction, even initial or silent.

July 5, 2011

Bedside diagnosing Acute Myocardial Infarction (AMI) is sometimes very difficult, particularly if initial or silent. On the other hand, the efficaciousness of therapeutic results, especially regarding mortality rate, depend of early AMI diagnosis (1-7).

In following, a Quantum Biophysical Semeiotics simple method, easily and quickly to apply, based on Gentile’s Sign, is fully illustrated.

Considering that glucose and lipid metabolism impairment worsens, BUT not brings about coronary artery disease (CAD), as I have demonstrated earlier (3-8), physician has to know CAD Inherited Real Risk, rapidly detected with the Caotino’s Sign (8), representing the condition sine qua non of CAD, especially in individuals involved by hypertension, diabetes mellitus, dyslipidemia, or elevated C-reactive protein.

In my long, well-established clinical experience, Gentile’s Sign proved to be really useful also in order to bed-side recognizing AMI, even silent or initial: impending infarction.
Importantly, it is known that patients with CAD may have no symptoms at all for many years or decades and that the electrocardiographic features of ischemia may be induced by exercise without accompanying angina (2, 7, 8). As a consequence, physicians need a clinical tool reliable in rapid detecting CAD, even clinically silent, initiating from CAD “inherited real risk. From the practical viewpoint, in order to apply Gentile’s Sign doctor has to know, at least, the auscultatory percussion of the stomach (1).

In health, digital pressure of “mean” intensity (= stimulation of both upper and lower ureteral reflex: vasomotility and respectively vasomotion, according to Hammersen), applied upon ventricle heart skin projection area = precordium), brings about the so-called gastric aspecific reflex (= in the stomach, fundus and body are dilated, while antral-pyloric region contracts) after a latency time of 8 sec. exactly; reflex duration is less than 4 sec. (= parameter value of paramount significance since it parallels the efficacy of local coronary microvessel Microcirculatory Functional Reserve). Finally, the reflex disappearing is > 3 sec. < 4 sec. (= parameter value paralleling fractal Dimension of local microcirculatory oscillations) (1-4) (Fig. 1).

On the contrary, in impending infarction and obviously in overt AMI, even silent or initial, latency time appears significantly lowered to 3-5 sec, in inverse relation with the seriousness of underlying disorder (NN = 8 sec.). Reflex lasts longer than normal: 4 sec. or more (NN = > 3 sec. < 4 sec.), directly correlated with the AMI severity.

Finally, nail-digital pressure on identical heart trigger-points, illustrated above, only in AMI patients bring about gastric aspecific refelex after a reduced latency time: 3-5 sec. (NN = 10 sec. or more)
When physicians will be able to apply Gentile’s Sign, and Caotino’s Sign, both morbidity and mortality caused by AMI will lowered significantly, and CAD will not be, as nowadays, a growing epidemics.

*Anna Gentile, MD. My Cardiologist, Sestri Levante Hospital, ASL 4, (Genova) Italy

References

1)Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/ semeiotica_biofisica.htm
2)Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 13, 109, 1997.
3)Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

4)Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004

5) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, http://www.travelfactory.it, Roma, 2009.

6)Stagnaro S. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7; [MEDLINE]

7) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn- Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. http://www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp

8) Sergio Stagnaro. Caotino’s Sign in bedside detecting CAD, since its initial Stage of CAD Inherited Real Risk. http://www.fce.it. 3 giugno 2010. http://www.fceonline.it/images/docs/caotino.pdf

 

Quantum Biophysical Semeiotics Demonstrates for the first Time the Water Memory-Information

July 1, 2011

Sergio Stagnaro*

This paper is dedicated to my friend Marcello Masci,
by whom I was told that Cem-Tech exist, even … in Italy!

Argument of large discussion, water memory is till now, 1 July 2011, a conjecture.
In fact, nobody has demonstrated that water is capable of retaining a memory (I like to add also INFORMATION) of substances once dissolved in it to arbitrary dilution.
The concept was notoriously proposed by Jacques Benveniste to explain the purported therapeutic powers of homeopathic remedies, which are prepared by diluting solutions to such a high degree that not even a single molecule of the original substance remains in most final preparations. Benveniste sought to prove this basic tenet of homeopathy by conducting an experiment to be published independently of homeopathic interests in a major journal.

Unfortunately, Jacques Benveniste and all other today’s scientists know Quantum Biophysical Semeiotics (www.semeiotica biofisica.it, and http://www.sisbq.org).

While some studies, including Benveniste’s, have reported such an effect, double-blind replications of the experiments involved have failed to reproduce the results, and the concept is not accepted by the scientific community, in my opinion, because we are living in Mean Ages Medicine, Ages of the Enlightenment out.

In following my CLINICAL, Quantum Biophysical Semeiotic, first Demonstration of Water Memory-Information.

Importantly, such a experimental evidence can be reproduced easily and quickly, at the condition that scientists, who want reproduce it, know the quantum biophysical semeiotic method!!!

Since four days, I am suffering from gastro-entero-colitis, caused by infected food, i.e., by bacteria Gram-positive in nature; probably enterococcus (I am going to ascertain with laboratory data, but it is not important for the experiment.

BASAL QBS evaluation showed increased acute antibody synthesis (See above mentioned website http://www.semeioticabiofisica.it): for instance, latency time of typical BALT- and Liver- Gastric Aspecific Reflex was 5 sec. (NN = 6 sec.).
In addition, the duration of both BALT and liver oscillations was 7 sec. (NN = 6 sec.) (ibidem).

At this point, I have captured with Cem Tech two devices (crystals) frequency from my transverse (immediately before splenic curvature) and initial descendent colon, for 1 minute.

After applying the two devices on myself, upon the same sites, cited above, I assessed for the second time the intensity of BALT and Liver acute antibody synthesis: latency time resulted significantly reduced to 3 sec., while the duration of both BALT and liver oscillations raised to 9 sec. (NN = 6 sec.).

Immediately thereafter, I went away from the Cem Tech devices, and repeated the evaluation of acute antibody synthesis, which showed the identical, basal value of latency time: 5 sec., namely, the antibody synthesis, without the influence of extremely high frequency of Cem Tech devices returned to the identical, basal parameter value: 5 sec.

At this moment, I directed the extremely high frequency of Cem Tech devices towards water, present in a glass (precisely: mineral wasser…), applying the two crystals directly on the glass wall for 10 minute.

After that, I located the glass with the water on the table, 10 cm from my body: the acute antibody synthesis increased again, raising to latency time of 3 sec., while the duration of both BALT and liver oscillations raised again to 9 sec. (NN = 6 sec.).

At this point, I go away from the water in the glass, and repeated the evaluation of acute antibody synthesis, which showed predictably the same, basal value of latency time: 5 sec., namely, the antibody synthesis, without the influence of extremely high frequency present CLEARLY in the water, returned to the identical, basal parameter value: 5sec.

Soon after I drunk that water, I observed identical, significant increasing of acute antibody synthesis, as described above under two experimental conditions: latency time resulted significantly reduced to 3 sec., while the duration of both BALT and liver oscillations was 9 sec.

I like to say that cleaned glass was inactive, i.e., it did not bring about stimulation of antibody synthesis.

Interestingly, now, when I am writing three hours after the experiment, all parameter values continue to be increased, as I illustrated above.
Successively, at my further control, the action was evident also after 6 hours!

Conclusion: My quantum-biophysical-semeiotic experiment, illustrated above in details, demonstrates CLINICALLY Water Memory-Information for the first time.

Sergio Stagnaro MD
Via Erasmo Piaggio 23/8,
16039 Riva Trigoso (Genoa) Italy
Founder of Quantum Biophysical Semeiotics,
Honorary President of International Society of
Quantum Biophysical Semeiotics (SISBQ)
Who’s Who in the World (and America)
since 1996
Ph 0039-0185-42315
Cell. 3338631439
http://www.semeioticabiofisica.it
http://www.sisbq.org
dottsergio@semeioticabiofisica.it