Renin-Angiotensin Blockade And Kidney Disease Inherited Real Risk.

in order to rightly evaluate possible beneficial action of renin-angiotensin blockade in preventing kidney diseases, physicians have to know as well as bedside recognize kidney disease inherited real risk (1-8). In fact, such overlooked congenital real risk represents the “condition sine qua non” of kidney disorder, different in nature.

As a consequence, renin-angiotensin blockade must be happen in individual properly enrolled, because kidney disorders will never occur in absence of renal inherited real risk. In addition, it is generally admitted that early diagnosis is the conditio sine qua non of the best therapeutic results. Unfortunately, renal disorders, including cancer, and other less common disorder of urinary tract are mainly recognized later, since for years or decades they are silent from the clinical view-point. The following easy manoeuvre plays a central role also in recognizing renal inherited real risk. In health, “light-moderate” persisting stimulation by cutaneous pintching of renal trigger-points, i.e., VIII-X thoracic dermatomeres (= lateral abdominal quadrants), after exact 8 sec. latency time, brings about aspecific gastric reflex: in the stomach, both fundus and body dilate, while antral-pyloric region contracts: Reflex duration lasts LESS than 4 sec.: such as parameter value, paralleling local Microcirculatory Functional Reserve, plays a paramount role in bedside excluding Renal Cancer, as well as all other kidney diseases, even in its first stage of inherited real risk, characterized by newborn-pathological, type I, subtype a) oncological, and b) aspecific Endoarteriolar Blocking Devices (6-8). On the contrary, in individual involved by Inherited oncological or aspecific Kidney Real Risk, including urinary way cancer, the identical stimulation causes aspecific gastric reflex, showing normal latency time (NN = 8 sec.), BUT its duration is 4 sec. or more, i.e. pathological.

Really, these two parameter values are inversely and respectively directly related to the seriousness of underlying disorders. Immediately there after, in oncological real risk only, one observes tonic Gastric Contraction, typical of tumoural lesion: Pollio’s Sign.

Interestingly, when renal trigger-points stimulation is “intense”, due to non local realm of biological system (8-10), all components of urinary tract are “simultaneously” stimulated: in health, reflex latency time raises from 8 sec. to 16 sec., because locally free energy is increased, due to type I, associated, microcirculatory activation (3-7). Interestingly, in subject involved by both Oncological Terrain and Inherited Oncological Real Risk in whatever part of urinary system (kidney, urinary bladder, and prostate), “intense” stimulation of a UNIQUE trigger-point causes “simultaneously” intense aspecific gastric reflex, immediately followed by great tonic Gastric Contraction: Pollio’s Sign, which surely will play a paramount role in RC as well as in urinary tract malignancies primary prevention. Subsequently, physicians will localized tumoural lesion with the aid of a lot of biophysical-semeiotic signs (1-7).


Pollio’s Sign. In memory of my dear friend, Fabrizio Pollio MD, brilliant gynaecologist surgeon, dead at age of 34 years for renal cancer.



1) Stagnaro Sergio. (7 February 2008). Bedside diagnosing prostate cancer inherited oncological real risk and its therapy. Annals of Internal Medicine.

2) Stagnaro Sergio. Oncogenesis is possible exclusively in individuals Oncological Terrain-positive. 2007.

3) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004.

4) Stagnaro S., Stagnaro-Neri M., La Melatonina nella Terapia del Terreno Oncologico e del “Reale Rischio” Oncologico. Travel Factory, Roma, 2004.

5) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004.

6) Stagnaro S., Stagnaro-Neri M., La Melatonina nella Terapia del Terreno Oncologico e del “Reale Rischio” Oncologico. Travel Factory, Roma, 2004.

7) Stagnaro Sergio. Oncological Terrain and Inherited Oncological Real Risk: New Way in Malignancy Primary Prevention and early Diagnosis. International Seminars in Surgical Oncology, 2007.

8) Stagnaro Sergio. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. The Lancet. March 06 2007.

9) Stagnaro Sergio e Paolo Manzelli. Semeiotica Biofisica: Realtà non-locale in Biologia. Dicembre 2007,,

10) Stagnaro Sergio e Paolo Manzelli. Semeiotica Biofisica Quantistica.

11) Stagnaro Sergio. Esperimento di Lory e Crisi dei Fondamenti della Medicina Occidentale. 17 Febbraio 2008


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: