Bedside Detecting Oesophagus Inherited Oncological Real Risk or overt cancer, even in initial stage.

I find really interesting the article “Dysphagia and an oesophageal stricture; not always cancer”K J Woittiez, W R ten Hove, J T M van der Heyden.
However, such as diagnosis is facilitated enormously if physicians could know Quantum Biophysical Semeiotics (,

In my view, based on 55 year-long clinical experience, doctors around the world have to know new and more efficacious screening types for malignancies, easy to perform on very large scale and reliable in ascertain also oesophagus cancer Oncological Terrain-Dependent, “inherited real risk” in well defined site of the oesophagus, or cancer initial stage in individuals always involved by oncological terrain, of course (1).

In fact, nowadays a new bed-side preventive medicine can be applied by all general practitioners worldwide in an efficient and practical manner (1-9) (See my site, Biophysical-Semeiotic Constitutions, as well as Practical Applications ).
As a matter of fact, nowadays, physicians, who knows the progresses of physical semeiotics, can recognize since birth clinically individuals at “inherited real” risk of malignancy, both solid and liquid, including their precise location (1, 2).
In following, I describe briefly an original physical sign, reliable in recognizing “inherite real risk” of oesophageal cancer, and thus usefull in primary preventing it, as well as in bed-side early detecting oesophagus Cancer, i.e. since very early stage, including Cancer “in situ” (1).
In health, lying down on supine position and psycho-physically relaxed with open eyes (=to lower melatonin secretion), a lasting cutaneous pinch at the level of oesophageal thoracic dermatomere, at right or left, brings about gastric aspecific reflex (in the stomach both fundus and body dilate, while antral-pyloric region contracts = tissue acidosis; see above-cited site, Technical Pages, n° 1), after a latency time (lt) of 8 sec.
The reflex lasts less than 4 sec. (paramount parameter value, which parallels local Microciirculatory Functional reserve) and then disappears for >3 < 4 sec., which informs on fractal dimension of local microvessel fluctuations. All parameters values are interesting from diagnostic point of view.
On the contrary, in case of oesophageal Cancer, even in initial stage, lt is < 8 sec., reflex duration 4 sec. or more and finally the entire stomach, soon theafter the reflex, contracts: Gastric tonic Contraction (GtC). This is a "pathological" parameter, typical of malignancy.
All parameters values, indicating local oesophageal micorcirculatory abnormalities (1-7), are in relation to the severity of underlying malignancy.
For instance, lt. becomes shorter than the normal 8 sec. in inverse relation to the exstension of tumour. Very useful and reliable (I perform it during physical examination, i.e., in every case, routinely) is the biophysical semeiotic "preconditioning" of oesophagus: after 5 sec. exactly of interval after the basal performance,doctor applys this method a second time (interval must be 5 sec. precisely, due to oesophageal microcirculatory functional reserve (MFR) activation):
in health, where there isn't GtC., all parameters value ameliorate significantly: e.g., latency time results 16 sec., i.e., a doubled value.
On the contrary, in oesophageal cancer, since first stages (even “in situ” cancer), as well as in "inherited real risk" of cancer, they worsen clearly or persist identical in latest case (1-11) .
Finally, thanks to Quantum Biophysical Semeiotics, in health, "intense" digital stimulation of a SINGLE oesophageal trigger-point, for instance the cutaneous pintschingat the immediately above sternum, aloong the middle line, does not cause "simultaneously" stomach modification, allowing doctors to exclude oesophagus disorder of whatever nature in less than one second!
On the contrary, in case of oesophagous Inherited Oncological Real Risk or overt cancer, since its initial stage, we observe above-illustrated stomac size changes, followed by characteristic tonic Gastric Contraction.
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004.
2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004.
3) Stagnaro Sergio. Bed-Side Prostate Cancer Detecting, even in early stages (“Real Risk” of Cancer): BMC Family Practice, 6:24 doi:10.1186/1471-2296-6-24

4) Sergio Stagnaro Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer (21 December 2005). Cancer Cell International

5) Stagnaro S. Genes and Cancer: a clinical view-point. The Oncological Terrain. BioMed Central Informatics, 2004.

6) Stagnaro S., Stagnaro-Neri M., Oncological Terrain, conditio sine qua non of Oncogenesis, GUT, 2004.

7) Stagnaro Sergio. "Genes, Oncological Terrain, and Breast Cancer", World Journal of Surgical Oncology. 2005,

8)Stagnaro Sergio. GPs , Biophysical Semeiotics, and bedside cancer diagnosis. 08 July 2007, International Seminar of Surgical Oncology,

9) Stagnaro Sergio. Overloking Oncological Terrain and oncological Real Risk, no paper is up-dated! 18 January 2008 Ann. Intern Med.

10) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory,, Roma, 2009.

11) Caramel S., Stagnaro S. The role of mitochondria and mit-DNA in Oncogenesis.
Quantum Biosystems 2010, 2, 221-248,



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